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KMID : 0614020050200010064
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Journal of Pharmaceutical Sciences (C.N.U.)
2005 Volume.20 No. 1 p.64 ~ p.72
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Optimazation for screening of environmental estrogenic compound, bisphenol A and studies of cell cytotoxicity
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Ahn Kwang-Hyun
Kim Bong-Hee
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Abstract
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Xenoestrogens are chemicals with diverse structure that mimic estrogen. Bisphenol A, a monomer of polycarbonate and epoxy resins, has been detected in canned food and human saliva. Bisphenol A stimulate cell proliferation and induce expression of estrogen-response genes in vitro. Bisphenol A shares similarities in structure, metabolism and action with DES(diethylstilbestrol), a known human teratogen and carcinogen. This thesis considers the hypothesis that Bisphenol A is converted in vivo to hydroxylated metabolites with reduced estrogencity and enhanced cytotoxicity. The purpose of the this study was to evaluate the cell proliferation of bisphenol A in the presence of a rat liver S9 mix.
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KEYWORD
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bisphenol A, cytotoxicity
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